Autoantibody clusters in rheumatoid arthritis are not driven by antigen specificity or isotype
Published in RMD Open, 2025
Autoantibodies are a key feature of rheumatoid arthritis (RA). They can be detected years before disease onset, but it is unknown if there is any pattern in the co-occurrence of antigen recognition or isotype profiles. A common signature could point to a unique initial trigger for autoantibody development. Therefore, we sought to determine if there is a pattern in antigen or isotype reactivity in pre-symptomatic cases and established RA.
Recommended citation: van Mourik AG, Johansson L, van Wesemael TJ, Maurits MP, Kokkonen H, Rönnelid J, Knevel R, Toes REM, Rantapää-Dahlqvist S, van der Woude D. (2025) "Autoantibody clusters in rheumatoid arthritis are not driven by antigen specificity or isotype" RMD Open. 2025 Jun 13;11(2):e005291. doi: 10.1136/rmdopen-2024-005291.
Recommended citation: van Mourik AG, Johansson L, van Wesemael TJ, Maurits MP, Kokkonen H, Rönnelid J, Knevel R, Toes REM, Rantapää-Dahlqvist S, van der Woude D. (2025) "Autoantibody clusters in rheumatoid arthritis are not driven by antigen specificity or isotype" RMD Open. 2025 Jun 13;11(2):e005291. doi: 10.1136/rmdopen-2024-005291.
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